期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 107, 期 6, 页码 R37-R45出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI11297
关键词
-
CCR6 expression in dendritic, T, and B cells suggests that this beta -chemokine receptor may regulate the migration and recruitment of antigen-presenting and immunocompetent cells during inflammatory and immunological responses. Here we demonstrate that CCR6(-/-) mice have underdeveloped Peyer's patches, in which the myeloid CD11b(+) CD11c(+) dendritic-cell subset is not present in the subepithelial dome. CCR6(-/-) mice also have increased numbers in T-cell subpopulations within the intestinal mucosa. In 2,4-dinitrofluorobenzene-induced contact hypersensitivity (CHS) studies, CCR6(-/-) mice developed more severe and more persistent inflammation than wild-type (WT) animals. Conversely, in a delayed-type hypersensitivity (DTH) model induced with allogeneic splenocytes, CCR6(-/-) mice developed no inflammatory response. The altered responses seen in the CHS and DTH assays suggest the existence of a defect in the activation and/or migration of the CD4(+) T-cell subsets that downregulate or elicit the inflammation response, respectively. These findings underscore the role of CCR6 in cutaneous and intestinal immunity and the utility of CCR6(-/-) mice as a model to study pathologies in these tissues.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据