期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
卷 1797, 期 6-7, 页码 952-960出版社
ELSEVIER
DOI: 10.1016/j.bbabio.2010.03.005
关键词
p66Shc; Ser36-P-p66Shc; Mitochondrial disorder; ROS; Antioxidant enzyme
资金
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
- Telethon [GGP09128] Funding Source: Medline
p66Shc, the growth factor adaptor protein, can have a substantial impact on mitochondrial metabolism through regulation of cellular response to oxidative stress. We investigated relationships between the extent of p66Shc phosphorylation at Ser36, mitochondrial dysfunctions and an antioxidant defense reactions in fibroblasts derived from five patients with various mitochondrial disorders (two with mitochondrial DNA mutations and three with methylglutaconic aciduria and genetic defects localized, most probably, in nuclear genes). We found that in all these fibroblasts, the extent of p66Shc phosphorylation at Ser36 was significantly increased. This correlated with a substantially decreased level of mitochondrial superoxide dismutase (SOD2) in these cells. This suggest that SOD2 is under control of the Ser36 phosphorylation status of p66Shc protein. As a consequence, an intracellular oxidative stress and accumulation of damages caused by oxygen free radicals are observed in the cells. (C) 2010 Elsevier B.V. All rights reserved.
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