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Solubilities of some nitrogen-containing drugs in supercritical carbon dioxide

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JOURNAL OF CHEMICAL AND ENGINEERING DATA
卷 46, 期 2, 页码 451-455

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AMER CHEMICAL SOC
DOI: 10.1021/je000286n

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The equilibrium solubilities of five nitrogen-containing drugs carbamazepine, diazepam, codeine, atropine, and lorazepam have been measured in supercritical carbon dioxide using a simple ana reliable static method. The measurements were performed in the pressure range (122 to 355) bar at the temperatures (308, 318,328, 338, and 348) K. The measured solubilities were correlated using a semiempirical model. The calculated results show satisfactory agreement with experimental data.

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