期刊
MOLECULAR CELL
卷 7, 期 3, 页码 539-549出版社
CELL PRESS
DOI: 10.1016/S1097-2765(01)00201-5
关键词
-
资金
- NIGMS NIH HHS [GM38810] Funding Source: Medline
The human snRNA promoters contain a proximal sequence element (PSE) required for basal transcription and a distal sequence element (DSE) required for activated transcription. The PSE recruits the multisubunit factor SNAP,, whereas the DSE recruits Oct-1. Oct-1 and SNAP, bind cooperatively to DNA when their respective binding sites are moved into proximity through a mechanism that involves a defined protein-protein contact. Here, we show that on the natural U6 promoter, cooperative binding of Oct-1 and SNAP, is mediated by a positioned nucleosome that resides between the DSE and the PSE. This cooperative binding requires the same protein-protein contact as cooperative binding to closely spaced sites on naked DNA and mediates transcription activation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据