期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
卷 1777, 期 7-8, 页码 860-866出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbabio.2008.05.442
关键词
mitochondria; fission; Fis1; autophagy
资金
- Telethon [TCR07002] Funding Source: Medline
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
Damaged mitochondria can be eliminated in a process of organelle autophagy, termed mitophagy. In most cells, the organization of mitochondria in a network could interfere with the selective elimination of damaged ones. In principle, fission of this network should precede mitophagy; but it is unclear whether it is per se a trigger of autophagy. The pro-fission mitochondrial protein Fisl induced mitochondrial fragmentation and enhanced the formation of autophagosomes which could enclose mitochondria. These changes correlated with mitochondrial dysfunction rather than with fragmentation, as substantiated by Fisl mutants with different effects on organelle shape and function. In conclusion, fission associated with mitochondrial dysfunction stimulates an increase in autophagy. (c) 2008 Elsevier B.V. All rights reserved.
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