期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 84, 期 1-2, 页码 159-162出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0162-0134(00)00203-8
关键词
titanocene dichloride; anti-cancer drugs; metallocenes
The compounds (eta (5)-C5H5)(2)TiCl2 (I), currently undergoing phase II trials, (eta (5)-C5H5)(eta (5)-C5H4CO2Me)TiCl2 (II) and (eta (5)- C5H4CO2Me)(2)TiCl2 (III) are assessed for their efficacies against a small lung cancer cell line. It is found that the introduction of the electron withdrawing carbomethoxy group into the cyclopentadienyl rings increases the effectiveness of this class of drugs, such that III compares favorably with the well known cisplatin. (C) 2001 Elsevier Science B.V. All rights reserved.
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