Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat

Orexin A (10-300 nM) strongly excited dorsal raphe serotonergic neurons maintained in vitro. The depolarization persisted in the presence of tetrodotoxin (TtX, 0.5 muM) and was associated with an increase in input resistance. These results have relevance in the context of food intake regulation and the disease, narcolepsy. (C) 2001 Elsevier Science Ltd. All rights reserved.