期刊
NEUROREPORT
卷 12, 期 3, 页码 441-444出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200103050-00004
关键词
autobiographical events; hippocampus; prefrontal cortex; recent and remote memories
The time-scale of hippocampal and neocortical involvement in memory retrieval is keenly debated. Using event-related fMRI we examined whether recollecting autobiographical and public event memories, ranging from the recent to the very remote, was associated with parametric changes in brain activity. A ventrolateral prefrontal region was sensitive to memory age, showing increased activation during retrieval of recent autobiographical events and subsequent parametric decrease with remoteness. While we observed modulation of hippocampal activity in relation to memory type (autobiographical events in particular), there was no evidence for sensitivity of this region to memory age. These findings are concordant with a view of hippocampal involvement in autobiographical memory retrieval throughout the lifetime. NeuroReport 12:441-444 (C) 2001 Lippincott Williams & Wilkins.
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