期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 193, 期 5, 页码 621-630出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.193.5.621
关键词
lymphoid tissue; lymphotoxin; interleukin 7; chemokines; chemotaxis
Mice deficient in lymphotoxin beta receptor (LT betaR) or interleukin 7 receptor alpha (IL-7R alpha) lack Peyer's patches (PPs). Deficiency in CXC chemokine receptor 5 (CXCR5) also severely affects the development of PPs. A molecular network involving these three signaling pathways has been implicated in PP organogenesis, but it remains unclear how they are connected during this process. We have shown that PP organogenesis is initiated at sites containing IL-7R alpha (+):lymphoid cells and vascular cell adhesion molecule (VCAM)-1/intercellular adhesion molecule (ICAM)-1 expressing nonlymphoid elements. Here we characterize these lymphoid and nonlymphoid components in terms of chemokine signals. The lymphoid population expresses CXCR5 and has a strong chemotactic response to B lymphocyte chemoattractant (BLC). Importantly, chemokines produced by VCAM-1(+)ICAM-1(+) nonlymphoid cells mediate the recruitment of lymphoid cells. Furthermore, we show that these VCAM-1(+)ICAM-1(+) cells are mesenchymal cells that are activated by lymphoid cells through the I;TPR to express adhesion molecules and chemokines. Thus, promotion of PP development relies on mutual interaction between mesenchymal and lymphoid cells.
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