期刊
MOLECULAR BRAIN RESEARCH
卷 87, 期 2, 页码 257-262出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0169-328X(01)00008-0
关键词
Alzheimer's disease; amyloid beta-peptide; DNA repair; epileptic seizure; glutamate; topoisomerase inhibitor
DNA damage has been documented in neurodegenerative conditions ranging from Alzheimer's disease to stroke. DNA-dependent protein kinase (DNA-PK) is involved in V(D)J recombination and DNA double strand break repair, and may play a role in cell death induced by DNA damage. We now report that cultured hippocampal neurons from severe combined immunodeficient (scid) mice which lack DNA-PK activity are hypersensitive to apoptosis induced by exposure to topoisomerase inhibitors, amyloid beta peptide (AP) and glutamate. A similar increased vulnerability of hippocampal CAI and CA3 neurons was observed in adult scid mice after kainate-induced seizures. Our results suggest that DNA-PK activity is important for neuron survival under conditions that may occur in neurological disorders. (C) 2001 Elsevier Science B.V. All rights reserved.
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