期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
卷 1511, 期 1, 页码 1-6出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0005-2736(01)00274-7
关键词
critical point; phase diagram; membrane; liquid mixture; immiscibility
资金
- NIAID NIH HHS [5R01AI13587-25] Funding Source: Medline
- NIGMS NIH HHS [R01 GM045928-09, R01 GM045928-07, R01 GM045928, GM 45928, R01 GM045928-08] Funding Source: Medline
Some binary mixtures of cholesterol and phospholipids in monolayers have thermodynamic phase diagrams with two upper miscibility critical points. This feature has been interpreted in terms of condensed complexes' between the phospholipid and cholesterol. The present work gives evidence for the formation of complexes with a common simple integral stoichiometry in binary mixtures of cholesterol and a series of five sphingomyelins where the amide-linked acyl chain length is varied. This indicates that these complexes have a distinct geometry even though they form a liquid phase. (C) 2001 Elsevier Science B.V. All rights reserved.
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