Pathophysiological relevance of mitochondria in NAD+ metabolism

Pyridine nucleotides are mostly stored within mitochondria where they are involved in different functions ranging from energy metabolism to cellular signaling. Here we discuss the mechanisms of mitochondrial NAD(+) metabolism and release that mag contribute to the crucial roles played by these organelles as triggers or amplifiers of physiological and pathological events. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.