期刊
BIOCHEMISTRY-MOSCOW
卷 74, 期 7, 页码 703-708出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0006297909070013
关键词
SIRT1; metabolism; calorie restriction; apoptosis
资金
- National High Technology Research and Development Program [2006AA02Z192]
- National Natural Sciences Foundation of China [30700386]
Sirtuins were originally defined as a family of oxidized nicotinamide adenine nucleotide (NAD(+))-dependent enzymes that deacetylate lysine residues on various proteins. The sirtuins are remarkably conserved throughout evolution from archae to eukaryotes. They were named after their homology to the Saccharomyces cerevisiae gene silent information regulator 2 (Sir2). The mammalian sirtuins, SIRT1-7, are implicated in a variety of cellular functions ranging from gene silencing, control of the cell cycle and apoptosis, and energy homeostasis. As SIRT1 is a nuclear protein and is the mammalian homolog most highly related to Sir2, it has been the focus of a large number of recent studies. Here we review some of the current data related to SIRT1 and discuss its mode of action and biological role in cellular and organismal models.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据