期刊
BIOCHEMISTRY-MOSCOW
卷 73, 期 13, 页码 1473-+出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0006297908130087
关键词
pore-forming proteins; adaptation; pore structure; apoptosis; nanotechnology
资金
- Russian Foundation [07-04-01706, 08-04-01424]
Pore-forming, proteins are powerful tools for adaptation of living organisms to environmental conditions. A wide range of these proteins isolated front various sources, from viruses to mammals, has been used for the analysis of their role in the processes of intra- and inter-species competition, defense, attack, and signaling. Here we review a large number of pore-forming proteins from the perspective of their functions. structures, and mechanisms of membrane penetration. Various mechanisms of cell damage, executed by these proteins in the course of formation of a pore and after its passing to conducting state, have been considered: endo- and exocytosis, lysis, necrosis, apoptosis, etc. The role of pore-forming proteins in evolution is discussed. The relevance of practical application of pore formers has been shown, including application in nanotechnological constructions.
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