期刊
BIOCHEMISTRY-MOSCOW
卷 73, 期 5, 页码 562-572出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S000629790805009X
关键词
cancer-associated antigens; autoantibodies; serological diagnostics of cancer
The appearance of antibodies to cancer-associated antigens in biological fluids (particularly, in blood sera) of cancer patients is now a well-established fact, and their detection by immunochemical methods is a promising approach to diagnostics of malignant neoplasms. In this review, we consider some immunobiological aspects of the most extensively studied cancer-associated B-cell antigens, various applications of autoantibodies as cancer biomarkers, and prospects for the use of antigen arrays for improving diagnostic sensitivity.
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