期刊
JOURNAL OF IMMUNOLOGY
卷 166, 期 6, 页码 3659-3662出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.166.6.3659
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- NHLBI NIH HHS [HL-56389] Funding Source: Medline
Inducible costimulator (ICOS) is a new member of the CD28/CTLA-4 family that is expressed on activated and germinal center (GC) T cells. Recently, we reported that ICOS-deficient mice exhibited profound defects in T cell activation and effector function. Ab responses in a T-dependent primary reaction and in a murine asthma model were also diminished. In the current study, we investigate the mechanism by which ICOS regulates humoral immunity and examine B cell GC reactions in the absence of ICOS, We found that ICOS-/- mice, when immunized with SRBC, had smaller GCs. Furthermore, IgG1 class switching in the GCs was impaired, Remarkably, GC formation in response to a secondary recall challenge was completely absent in ICOS knockout mice. These data establish a critical role of ICOS in regulation of humoral immunity.
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