期刊
JOURNAL OF IMMUNOLOGY
卷 166, 期 6, 页码 3908-3914出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.166.6.3908
关键词
-
类别
资金
- NCI NIH HHS [CA57855, CA25803] Funding Source: Medline
p53 is an attractive target for cancer immunotherapy because it is overexpressed in a high proportion of many different types tumors, However, it is also expressed in normal tissues and acts as a toleragen in vivo, Previously, detailed examination of the repertoire specific for the murine p53(261-269) epitope in conventional and p53-deficient mice demonstrated that because of expression of p53, the CD8(+) T cells that respond to this epitope express low-affinity TCRs, It has been reported that tolerance to tumor Ags Can be broken by in vivo administration of anti-CTLA-4 mAb, With the goal of overriding tolerance and achieving optimal activation of p53-specific CTL, the current study has assessed the effect of anti-CTLA-4 mAb on the p53-specific repertoire. It was found that blockade of CTLA-4 engagement at the time of antigenic stimulation induced a vigorous amplification of the CTL responses to p53 as well as proportionate expansion of the memory T cell pool. This effect was dependent on the presence of CD4(+) T cell help and correlated with an enhancement of helper function. However, anti-CTLA-4 treatment did not enhance the avidity of the resultant p53-specific CTL populations and, therefore, could not reverse this important consequence of tolerance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据