期刊
JOURNAL OF INFECTIOUS DISEASES
卷 183, 期 6, 页码 871-879出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/319266
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In the absence of opsonizing antibodies, Bordetella pertussis, the causative agent of pertussis, readily binds to phagocytes via complement receptor 3 (CR3). After opsonization with antibodies, binding is mediated by IgG receptors (Fc gammaR). The effect of targeting B. pertussis to either Fc gammaR or CR3 was studied. The fate of unopsonized B. pertussis, IgG-opsonized B. pertussis, and B. pertussis opsonized with bispecific antibodies (BsAbs) directed to CR3 or Fc gamma RII/-III was compared. IgG antibodies mediated binding and phagocytosis of B. pertussis via Fc gammaR by polymorphonuclear leukocytes (PMNL) in vitro. Opsonization of B. pertussis with BsAbs directed against either CR3 or Fc gamma RII/-III facilitated PMNL phagocytosis; however, in vivo studies with BsAb revealed that Fc gammaR-mediated uptake facilitates B. pertussis clearance, in contrast to uptake via CR3. Targeting of B. pertussis to Fc gamma RII/-III in mice deficient in Fc gamma RII or Fc gamma RIII indicated that the protective effect is attributable to Fc gamma RIII. Competition between uptake via CR3 or Fc gammaR may determine the outcome of natural infection.
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