期刊
GENES & DEVELOPMENT
卷 15, 期 6, 页码 789-802出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.857401
关键词
TEF; combinatorial control; zinc finger proteins; cell differentiation; transcriptional control
资金
- NIGMS NIH HHS [R01 GM030997, GM30997, R37 GM030997] Funding Source: Medline
In wild-type Caenorhabditis elegans, six cells develop as receptors for gentle touch. In eg1-44 and eg1-46 mutants, two other neurons, the FLP cells, express touch receptor-like features. eg1-44 and eg1-46 also affect the differentiation of other neurons including the HSN neurons, two cells needed for egg laying, eg1-44 encodes a member of the transcription enhancer factor family. The product of the eg1-46 gene, two Drosophila proteins, and two proteins in human and mice define a new family of zinc finger proteins. Both eg1-44 and eg1-46 are expressed in FLP and HSN neurons (and other cells); expression of eg1-46 is dependent on eg1-44 in the FLP cells but not in the HSN cells. Wild-type touch cells express egl-46 but not eg1-44. Moreover, ectopic expression of eg1-44 in the touch cells prevents touch cell differentiation in an egl-46-dependent manner. The sequences of these genes and their nuclear location as seen with FLP fusions indicate that they repress transcription of touch cell characteristics in the FLP cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据