期刊
FEBS LETTERS
卷 492, 期 3, 页码 247-253出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(01)02258-X
关键词
interleukin-6; signal transducer and activator of transcription-3; transforming growth factor-beta; Sma- and MAD-related protein; p300; cross-talk; transcription
Interleukin-6 (IL-6) is a multifunctional cytokine that plays important roles in the immune system, hematopoiesis, and acute phase reactions. Transforming growth factor-beta (TGF-beta) also has pleiotropy including the production of acute phase proteins in hepatocytes, To elucidate the cross-talk between IL-6 and TGF-beta signaling pathways in hepatic cells, we investigated the effects of TGF-beta on IL-6-induced signal transducer and activator of transcription-3 (STAT3) activation in a human hepatoma cell line, Hep3B, IL-6-induccd activation of STAT3 activity and STAT3-mediated gene expression were augmented by TGF-beta in Hep3B cells, We provide evidence that these activities were due to physical interactions between STAT3 and Sma- and MAD-related protein-3, bridged by p300. These results demonstrate a molecular mechanism of a cross-talk between STAT3 and TGF-beta signaling pathways in hepatocytes, (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据