期刊
BRAIN RESEARCH
卷 894, 期 2, 页码 255-265出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(01)02024-8
关键词
beta-thymosin; actin binding protein; neuron; glia; angiogenesis
The beta -thymosins are a family of actin monomer-sequestering proteins widely distributed among vertebrate classes. The most abundant beta -thymosins in mammalian species are thymosin beta (4), (T beta,) and thymosin beta (10) (T beta (10)), two small peptides (43 amino acids) sharing a high degree of sequence homology. In the present work, we have analyzed the distribution of T beta (4) and T beta (10) in the developing and adult rat cerebellum using in situ hybridization and immunohistochemistry techniques. Our results show that the temporal and cellular patterns of expression of both beta -thymosins are different. In the young (7 and 18 postnatal days) and adult (1 and 4 months old) rat cerebellum, T beta (4) was mainly expressed in the glia (microglia, Golgi epithelial cells and oligodendrocytes), neurons (granule cells and Purkinje cells), and in the capillaries. In 14-month-old rats, the T beta (4) immunoreactivity was only detected in some microglia cells. In young and adult animals, most of the T beta (4) immunoreactivity was localized in several types of neuronal cells including granule cells, Golgi neurons and Purkinje cells. In old animals, a faint T beta (10) signal could be detected in a few Purkinje cells. Our results suggest that each beta -thymosin could play a different function in the control of actin dynamics. (C) 2001 Elsevier Science B.V. All rights reserved.
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