期刊
BIOCHEMISTRY AND CELL BIOLOGY
卷 89, 期 1, 页码 12-23出版社
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
DOI: 10.1139/O10-114
关键词
WSTF; WICH; WINAC; B-WICH; ATP-dependent chromatin remodeling complex; vitamin D; DNA repair; H2A.X; tyrosine 142
资金
- NCRR NIH HHS [RR016466, P20 RR016466-11, P20 RR016466] Funding Source: Medline
- NEI NIH HHS [R15 EY016027-02, EY016029-02] Funding Source: Medline
Williams syndrome transcription factor (WSTF) has emerged as an incredibly versatile nuclear protein. WSTF and the ATP-dependent chromatin remodeling complexes in which it exists, WINAC, WICH, and B-WICH, have been studied in a variety of organisms. This research has revealed roles for WSTF in a number of diverse molecular events. WSTF function includes chromatin assembly, RNA polymerase I and III gene regulation, vitamin D metabolism, and DNA repair. In addition to functioning as a subunit of several ATP-dependent chromatin remodeling complexes, WSTF binds specifically to acetylated histones and is itself a histone kinase as well as a target of phosphorylation. This review will describe the three known WSTF-containing complexes and discuss their various roles as well as mechanisms of regulating WSTF activity.
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