4.8 Article

Synthesis and characterization of fluorescent cobalamin (CobalaFluor) derivatives for imaging

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卷 3, 期 6, 页码 799-801

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AMER CHEMICAL SOC
DOI: 10.1021/ol006825v

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  1. NCI NIH HHS [CA73003] Funding Source: Medline

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[GRAPHICS] Fluorescent derivatives of cobalamin have been prepared by linking fluorophores to cobalamin through a propylamide spacer. Fluorescein, naphthofluorescein, and Oregon Green derivatives have been prepared in good yield by reaction of the fluorophore NHS-ester with beta-(3-aminopropyl)cobalamin to form fluorescent cobalamin conjugates (CobalaFluors) that are potentially suitable for the in vitro and in vivo imaging of transcobalamin receptors on cancer cells.

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