期刊
SCIENCE
卷 291, 期 5512, 页码 2413-2417出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1058867
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资金
- NIAID NIH HHS [AI41576, T32-AI07080] Funding Source: Medline
- NIDDK NIH HHS [DK45260] Funding Source: Medline
Many intracellular pathogens infect a broad range of host tissues, but the importance of T cells for immunity in these sites is unclear because most of our understanding of antimicrobial T cell responses comes from analyses of lymphoid tissue. Here, we show that in response to viral or bacterial infection, antigen-specific CD8 T cells migrated to nonlymphoid tissues and were present as Long-Lived memory cells. Strikingly, CD8 memory T cells isolated from nonlymphoid tissues exhibited effector Levels of Lytic activity directly ex vivo, in contrast to their splenic counterparts. These results point to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection.
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