期刊
NEUROREPORT
卷 12, 期 4, 页码 739-743出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200103260-00025
关键词
dorsal root ganglia; neuropeptide; pain; primary afferents; sensory processing
Using immunohistochemistry and in situ hybridization the expression of calcitonin gene-related peptide (CGRP) was studied in the mouse spinal cord under normal conditions and after unilateral rhizotomy and after local colchicine treatment. Under normal conditions a dense plexus of CGRP-immunoreactive (IR) fibres was observed in the superfical layers of dorsal horns with lower numbers of fibers in deeper laminae. Seven days after unilateral rhizotomy, there was a marked reduction of CGRP-IR fibres in the ipsilateral superfical layers and distinctly CGRP-IR neurons could be detected in the ipsilateral lamina III. CGRP mRNA-positive neurons were observed in lamina III in both the ipsilateral and contralateral dorsal horn. Colchicine treatment did not markedly increase the number of CGRP-IR neurons. The results suggest that CGRP is synthesized in local dorsal horn neurons of the mouse, and these neurons presumably participate in sensory processing. NeuroReport 12:739-743 (C) 2001 Lippincott Williams & Wilkins.
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