期刊
NEUROREPORT
卷 12, 期 4, 页码 803-807出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200103260-00037
关键词
D1 and D2 receptor; dopamine; sodium channel; spiral ganglion; whole-cell recording
资金
- NIDCD NIH HHS [P01 DC03600-01A1] Funding Source: Medline
Lateral olivocochlear (LOC) efferent neurons, putatively dopaminergic, synapse on afferent dendrites of type I spiral ganglion neurons (SGNs) in the cochlea and depress their activity. To investigate the underlying mechanisms, whole-cell patch clamp recordings were obtained from mouse SGNs. Dopamine (DA), and D1-like (D1, D5) and D2-like (D2, D3 and D4) receptor agonists, reduced AP amplitude and induced a slow transient depolarization. Under voltage clamp, D1-like and D2-like agonists induced a dose-dependent inward current that was reversibly blocked by their receptor antagonists. The inward current was blocked by tetrodotoxin (TTX), implicating Na+ channels. The reduction of AP amplitude and voltage-gated Na+ current by DA and DA agonists provides a mechanism for suppressing spike activity in type I afferent neurons. NeuroReport 12:803-807 (C) 2001 Lippincott Williams & Wilkins.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据