期刊
PHYSIOLOGY & BEHAVIOR
卷 72, 期 5, 页码 691-703出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0031-9384(01)00442-5
关键词
flavor conditioning; sugar; postingestive signal
资金
- NIDDK NIH HHS [DK-31135] Funding Source: Medline
- NIMH NIH HHS [MH-00983] Funding Source: Medline
Many prior conditioning studies indicate that fructose, unlike glucose, has minimal postingestive reinforcing effects. Using a new training procedure, food-restricted rats were trained in alternate 20-h/day sessions with one flavored solution (CS+F) paired with intragastric Od) infusions of 16% fructose and another flavor (CS-) paired with IG water. In subsequent two-bottle tests they showed a robust (85%) preference for the CS+F over the CS-. A third flavor (CS+G) was then paired with IG 16% glucose, and it was strongly preferred to the CS+F. When retrained 30 min/day with new flavors paired with IG fructose, glucose, or water the rats learned only a CS+G preference. When training was extended to 20 h/day, a CS+F preference developed. New rats trained 20 h/day with two-bottle access to CS+F and CS- paired with IG fructose and water failed to acquire a CS+F preference. Other rats rapidly developed a strong preference when trained with concurrent access to CS+G and CS- paired with IG glucose and water. These data indicate that both fructose and glucose generate postingestive reinforcing signals, but that the fructose signals are weaker and/or delayed relative to those produced by glucose. (C) 2001 Elsevier Science Inc. All rights reserved.
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