期刊
JOURNAL OF BIOMECHANICS
卷 48, 期 12, 页码 3349-3355出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2015.06.016
关键词
MRI; 3 T T-2 Mapping; Articular cartilage; In vivo cartilage loading; Autologous chondrocyte transplantation
资金
- Austrian Science Fund (FWF) [P 25246 B24]
- Vienna Advanced Imaging Center (VIACLIC) des Wiener Wissenschafts-, Forschungs- und Technologiefonds (WWTF) [FA102A0017]
- Slovak Scientific Grant Agency VEGA [VEGA2/0013/14]
Magnetic resonance (MR) transverse relaxation time (T-2) mapping has been frequently used to evaluate collagen content and its organization. In this study, MR T-2 mapping, using the multi-slice, multi-echo Carr-Purcell-Meiboom-Gill technique, was performed in volunteers and patients after matrix-associated autologous chondrocyte transplantation (MACT) under unloading and loading conditions with an MR-compatible compression device. In the volunteer study, a statistically significant decrease in the cartilage MR T-2 values was observed during the loading phase when compared to the initial load-free measurement. During the recovery period, a statistically significant increase in the T-2 values was found in the central superficial layer (p=0.001), the central deep layer (p=0.005), the posterior deep layer (p= 0.001), and in the tibia superficial layer (p=0.01) when compared to measurements under loading. In patients after MACT, during unloading or loading conditions, statistically significant changes in T-2 values were observed in the transplant deep zone (p = 0.005), in the posterior deep zone (p=0.004), and in the tibia superficial zone (p =0.012). The results of this study show that MR T-2 mapping under loading conditions may provide additional information about cartilage repair tissue composition and organization during the postoperative follow-up, and may help to evaluate the efficacy of cartilage-repair surgery techniques. (C) 2015 Elsevier Ltd. All rights reserved.
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