期刊
JOURNAL OF BACTERIOLOGY
卷 183, 期 7, 页码 2380-2383出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.183.7.2380-2383.2001
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资金
- NIAID NIH HHS [R56 AI042756, AI42756, R01 AI042756] Funding Source: Medline
- NIGMS NIH HHS [GM47446, R01 GM047446] Funding Source: Medline
We demonstrate that the Bacillus subtilis fosB(yndN) gene encodes a fosfomycin resistance protein. Expression of fosB requires sigma (W), and both fosB and sigW mutants are fosfomycin sensitive. FosB is a metallothiol transferase related to the FosA class of Mn2+-dependent glutathione transferases but with a preference for Mg2+ and L-cysteine as cofactors.
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