期刊
ANALYST
卷 140, 期 11, 页码 3731-3737出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5an00207a
关键词
-
资金
- NHLBI [HL117048]
- NIH [S10-OD010344, U54-CA151459, P50-CA114747]
- U.S. Department of Energy (DOE) Office of Basic Energy Sciences [DE-FG02-01ER15186]
Chemical tools that can report radioactive isotopes would be of interest to the defense community. Here we report similar to 250 nm polymeric nanoparticles containing porphyrinoid macrocycles with and without pre-complexed depleted uranium and demonstrate that the latter species may be detected easily and with high sensitivity via photoacoustic imaging. The porphyrinoid macrocycles used in the present study are non-aromatic in the absence of the uranyl cation, but aromatic after cation complexation. We solubilized both the freebase and metalated forms of the macrocycles in poly(lactic-co-glycolic acid) and found a peak in the photoacoustic spectrum at 910 nm excitation in the case of the uranyl complex. The signal was stable for at least 15 minutes and allowed detection of uranium concentrations down to 6.2 ppb (5.7 nM) in vitro and 0.57 ppm (19 fCi; 0.52 mu M) in vivo. To the best of our knowledge, this is the first report of a nanoparticle that detects an actinide cation via photoacoustic imaging.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据