期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 21, 期 4, 页码 396-403出版社
NATURE PUBLISHING GROUP
DOI: 10.1097/00004647-200104000-00008
关键词
BMS-204352; potassium channels; head injury; cerebral edema; neuromotor function; cognition
资金
- NIGMS NIH HHS [R01-GM34690] Funding Source: Medline
- NINDS NIH HHS [P50-NSO8803] Funding Source: Medline
Large-conductance, calcium-activated potassium (maxi-K) channels regulate neurotransmitter release and neuronal excitability, and openers of these channels have been shown to be neuroprotective in models of cerebral ischemia. The authors evaluated the effects of postinjury systemic administration of the maxi-K channel opener, BMS-204352, on behavioral and histologic outcome after lateral fluid percussion (PP) traumatic brain injury (TBI) in the rat. Anesthetized Sprague Dawley rats (n = 142) were subjected to moderate FP brain injury (n = 88) or surgery without injury(n = 54) and were randomized to receive a bolus of 0.1 mg/kg BMS-204352 (n = 26, injured; n = 18, sham), 0.03 mg/kg BMS-201352 (n = 25, injured; n = 18, sham), or 2% dimethyl sulfoxide (DMSO) in polyethylene glycol (vehicle, n = 27, injured; n = 18. sham) at IO minutes postinjury. One group of rats was tested for memory retention (Morris water maze) at 42 hours postinjury, then killed for evaluation of regional cerebral edema. A second group of injured/sham rats was assessed for neurologic motor function from 48 hours to 2 weeks postinjury and cortical lesion area. Administration of 0.1 mg/kg BMS-204352 improved neurologic motor function at 1 and 2 weeks postinjury (P < 0.05) and reduced the extent of cerebral edema in the ipsilateral hippocampus, thalamus, and adjacent cortex (P < 0.05). Administration of 0.03 mg/kg EMS-204352 significantly reduced cerebral edema in the ipsilateral thalamus (P < 0.05). No effects on cognitive function or cortical tissue loss were observed with either dose. These results suggest that the novel maxi-a channel opener BMS-204352 may be selectively beneficial in the treatment of experimental TBI.
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