期刊
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
卷 280, 期 4, 页码 H1427-H1433出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.2001.280.4.H1427
关键词
pressure-induced constriction; focal adhesion; protein tyrosine phosphorylation; cytoskeleton; focal adhesion kinase; Src kinase; extracellular matrix; dense plaque
This review summarizes what is currently known about the role of integrins in the vascular myogenic response. The myogenic response is the rapid and maintained constriction of a blood vessel in response to pressure elevation. A role for integrins in this process has been suggested because these molecules form an important mechanical link between the extracellular matrix and the vascular smooth muscle cytoskeleton. We briefly summarize evidence for a general role of integrins in mechanotransduction. We then describe the integrin subunit combinations known to exist in smooth muscle and the vascular wall matrix proteins that may interact with these integrins. We then discuss the effects of integrin- specific peptides and antibodies on vascular tone and on calcium entry mechanisms in vascular smooth muscle. Because integrin function is linked to the cytoskeleton, we discuss evidence for the role of the cytoskeleton in determining myogenic responsiveness. Finally, we analyze evidence that integrin- linked signaling pathways, such as those involving protein tyrosine phosphorylation cascades and mitogen- activated protein kinases, are required for myogenic tone.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据