期刊
BIOCHEMISTRY
卷 52, 期 20, 页码 3405-3414出版社
AMER CHEMICAL SOC
DOI: 10.1021/bi400054p
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资金
- National Institutes of Health [EB002058]
Glycopeptides whose aminosugars have been modified by attachment of hydrophobic side chains are frequently active against vancomycin-resistant microorganisms. We have compared the conformations of six such fluorinated glycopeptides (with side chains of varying length) complexed to cell walls labeled with D-[1-C-13]alanine, [1-C-13]glycine, and L-[epsilon-N-15]lysine in whole cells of Staphylococcus aureus. The internuclear distances from F-19 of the bound drug to the C-13 and N-15 labels of the peptidoglycan, and to the natural abundance P-31 of lipid membranes and teichoic acids, were determined by rotational echo double resonance NMR. The drugs did not dimerize, and their side chains did not form membrane anchors but instead became essential parts of secondary binding to pentaglycyl bridge segments of the cell wall peptidoglycan.
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