期刊
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
卷 57, 期 1, 页码 47-49出版社
SPRINGER-VERLAG
DOI: 10.1007/s002280100264
关键词
CYP2C9; genotype; allele frequency
Objective: To search for ethnic variability in the impact of cytochrome P-450 2C9 (CYP2C9) polymorphism. Methods: CYP2C9 allelic variants related to impaired CYP2C9 metabolism were analysed in genomic DNA from 157 Spanish healthy subjects using amplification-restriction and sequencing procedures. Results: The frequency for CYP2C9 mutated alleles is higher among the Spanish subjects analysed than that reported for other Caucasian individuals: CYP2C9*2. 0.143 and CYP2C9*3, 0.162 (P = 0.0001), Nearly 10% of the individuals studied are expected to metabolise deficiently CYP2C9 substrates. Conclusion: In some Caucasian populations the impact of the CYP2C9 polymorphism may be much higher than that estimated from genotyping studies published to date.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据