期刊
TRENDS IN IMMUNOLOGY
卷 22, 期 4, 页码 194-199出版社
ELSEVIER SCI LTD
DOI: 10.1016/S1471-4906(01)01861-0
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The stable assembly of MHC class I molecules with peptides in the endoplasmic reticulum (ER) involves several accessory molecules. One of these accessory molecules is tapasin, a transmembrane protein that tethers empty class I molecules to the peptide transporter associated with antigen processing (TAP). Here, evidence is presented that tapasin retains class I molecules in the ER until they acquire high-affinity peptides.
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