期刊
JOURNAL OF BIOMECHANICS
卷 48, 期 8, 页码 1397-1406出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2015.02.043
关键词
Knee joint; Articular cartilage; Meniscectomy; Cell mechanics; Finite element analysis; Multi-scale modeling
资金
- European Research Council under the European Union's Seventh Framework Programme (FP), ERC Grant [281180]
- Academy of Finland [138574]
- Finnish Cultural Foundation North Savo regional fund [65142194]
- Kuopio University Hospital (EVO/VTR grant) [5041742]
- Sigrid Juselius Foundation
- Academy of Finland (AKA) [138574, 138574] Funding Source: Academy of Finland (AKA)
Mechanical signals experienced by chondrocytes (articular cartilage cells) modulate cell synthesis and cartilage health. Multi-scale modeling can be used to study how forces are transferred from joint surfaces through tissues to chondrocytes. Therefore, estimation of chondrocyte behavior during certain physical activities, such as walking, could provide information about how cells respond to normal and abnormal loading in joints. In this study, a 3D multi-scale model was developed for evaluating chondrocyte and surrounding pen-and extracellular matrix responses during gait loading within healthy and medial meniscectomy knee joints. The knee joint geometry was based on MRI, whereas the input used for gait loading was obtained from the literature. Femoral and tibial cartilages were modeled as fibril-reinforced poroviscoelastic materials, whereas menisci were considered as transversely isotropic. Fluid pressures in the chondrocyte and cartilage tissue increased up to 2 MPa (an increase of 30%) in the meniscectomy joint compared to the normal, healthy joint. The elevated level of fluid pressure was observed during the entire stance phase of gait. A medial meniscectomy caused substantially larger (up to 60%) changes in maximum principal strains in the chondrocyte compared to those in the pen-or extracellular matrices. Chondrocyte volume or morphology did not change substantially due to a medial meniscectomy. Current findings suggest that during walking chondrocyte deformations are not substantially altered due to a medial meniscectomy, while abnormal joint loading exposes chondrocytes to elevated levels of fluid pressure and maximum principal strains (compared to strains in the pen-or extracellular matrices). These might contribute to cell viability and the onset of osteoarthritis. (C) 2015 Elsevier Ltd. All rights reserved.
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