期刊
CURRENT OPINION IN MICROBIOLOGY
卷 4, 期 2, 页码 172-177出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/S1369-5274(00)00184-3
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in Escherichia coli, the iron regulator Fur is regulated by two oxidative-stress response regulators. The generation of dangerous radicals by oxygen and iron is the basis for this dual regulation, which is also found in eukaryotes, The binding of iron-regulated transcripts to apo-aconitase and results of mRNA half-life studies indicate that there is post-transcriptional iron regulation in bacteria, as in eukaryotes, Fur contains two metal-binding sites, one for Zn2+ and one for Fe2+. Zinc uptake systems are regulated by members of the Fur protein family, and zinc is a cofactor. DtxR and related proteins constitute another family of iran regulators, first found in Gram-positive organisms with a high GC content, In organisms with Fur-dependent iron regulation, members of the DtxR family regulate manganese transport.
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