期刊
BIOCHEMISTRY
卷 51, 期 16, 页码 3321-3333出版社
AMER CHEMICAL SOC
DOI: 10.1021/bi201215r
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资金
- NIBIB NIH HHS [T32 EB009419] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007596] Funding Source: Medline
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1157892] Funding Source: National Science Foundation
Precursor-mRNA splicing is catalyzed by an extraordinarily large and highly dynamic macromolecular assemblage termed the spliceosome. Detailed biochemical and structural study of the spliceosome presents a formidable challenge, but there has recently been significant progress made on this front highlighted by the crystal structure of a 10-subunit human U1 snRNP. This review provides an overview of our current understanding of the architecture of the spliceosome and the RNA-protein complexes integral to its function, the U snRNPs.
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