期刊
CONTACT DERMATITIS
卷 44, 期 4, 页码 229-234出版社
MUNKSGAARD INT PUBL LTD
DOI: 10.1034/j.1600-0536.2001.044004229.x
关键词
irritant contact dermatitis; skin barrier recovery; moisturizer efficacy testing; sodium lauryl sulfate; transepidermal water loss; laser Doppler flowmetry; electrical capacitance; Derma-Spectrometer; bioengineering methods; skin-care products
Moisturizers are widely used to treat irritant contact dermatitis (ICD). Their use is, however, not well-documented and standardized models for testing skin care products are needed to acquire documentation of their efficacy. The present study was undertaken to evaluate the effect of 6 commonly-used moisturizers on the recovery of irritated human skin. No commercial interests were involved in the study. 36 healthy volunteers had patch tests with SLS 0.5% applied on their forearms/upper arms for 24 h. After irritation of the skin, all volunteers had a moisturizer applied on one forearm/upper arm, respectively, 3 X daily for the following 5 days. The other forearm/ upper arm served as an untreated control. Each moisturizer was tested on 12 volunteers and each volunteer tested 2 moisturizers at the same time. Evaluation was done on days 1, 3 and 8 by transepidermal water loss, electrical capacitance, laser Doppler flowmetry, DermaSpectrometry and clinical scoring. All 6 moisturizers were found to accelerate regeneration of the skin barrier function when compared to irritated non-treated skin. The most lipid-rich moisturizers improved barrier restoration more rapidly than the less lipid-rich moisturizers. We suggest this experimental model for further moisturizer efficacy testing.
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