期刊
BIOCHEMISTRY
卷 51, 期 23, 页码 4627-4629出版社
AMER CHEMICAL SOC
DOI: 10.1021/bi300522s
关键词
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资金
- U.K. Biotechnology and Biological Sciences Research Council (BBSRC)
- Bayer Animal Health
- EU
- BBSRC
- BBSRC [BBS/E/C/00005193, BB/F009143/1] Funding Source: UKRI
- EPSRC [EP/H043888/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/C/00005193, BB/F009143/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/H043888/1] Funding Source: researchfish
Neonicotinoid insecticides target nicotinic acetylcholine receptors (nAChR) in the nervous system of insects but are largely ineffective against ticks. This study aimed to identify the molecular basis for this insensitivity. A homology model of the nAChR binding domain was generated on the basis of the crystal structure of an acetylcholine-binding protein with the insecticide imidacloprid bound. We hypothesized that tick beta-subunits would differ at a critical residue (Arg81) in their D loops. To test this, we sequenced nAChR genes from five tick species and found that instead of the conserved arginine found in insects, a glutamine was present in all the tick sequences.
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