期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 185, 期 2, 页码 129-134出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0022-510X(01)00481-6
关键词
dementia with Lewy bodies; substantia nigra; central amygdaloid nucleus; spongy change; spheroid; immunohistochemistry; psychotic symptom
We neuropathologically and immunohistochemically investigated characteristics of the central amygdaloid nucleus lesion and its relationship with the substantia nigra lesion in dementia with Lewy bodies (DLB) brains. Nine DLB. four Parkinson's disease (PD) and four Alzheimer-type dementia (ATD) cases were examined. The degree of neuronal loss in the substantia nigra was (+)-(+ + +) in DLB cases, (+ + +) in PD cases and (+)in ATD cases. All DLB cases showed spongy change and ubiquitin-positive spheroids in the central nucleus. The degree of spongy change was (+)-(+ + +) in DLB cases, (+) in PD cases and (-)-(+) in ATD cases, which was correlated with the degree of neuronal loss in the substantia nigra in DLB cases. The number of ubiquitin-positive spheroids was parallel to the degree of spongy change. The central nucleus receives dense dopaminergic fibers from the substantia nigra. Many ubiquitin-positive spheroids were also positive to alpha -synuclein and tyrosine-hydroxylase, suggesting that they derive from the degeneration of terminal or distal axons of Lewy body-bearing dopaminergic neurons in the substantia nigra. The disturbance of the dopaminergic connections from the substantia nigra to the central nucleus may be responsible for psychotic symptoms in DLB patients. (C) 2001 Elsevier Science B.V. All rights reserved.
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