期刊
NATURE IMMUNOLOGY
卷 2, 期 4, 页码 301-306出版社
NATURE AMERICA INC
DOI: 10.1038/86302
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- NCI NIH HHS [CA10815] Funding Source: Medline
- NEI NIH HHS [5T32EY07131] Funding Source: Medline
- NIAID NIH HHS [AI24541] Funding Source: Medline
- NIAMS NIH HHS [5T32AR07442] Funding Source: Medline
Despite accumulating evidence that regulatory T cells play a crucial role in preventing autoimmunity, the processes underlying their generation during immune repertoire formation are unknown. We show here that interactions with a single self-peptide can induce thymocytes that bear an autoreactive T cell receptor (TCR) to undergo selection to become CD4(+)CD25(+) regulatory T cells. Selection of CD4(+)CD25(+) thymocytes appears to require a TCR with high affinity for a self peptide because thymocytes that bear TCRs with low affinity do not undergo selection into this pathway. Our findings indicate that specificity for self-peptides directs the selection of CD4(+)CD25(+) regulatory thymocytes by a process that is distinct from positive selection and deletion.
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