期刊
BIOLOGICAL PSYCHIATRY
卷 49, 期 7, 页码 644-652出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0006-3223(00)01013-1
关键词
anorexia nervosa; fluoxetine; SSRI; relapse prevention
Background: Anorexia nervosa is an often chronic disorder with high morbidity and mortality Many people relapse after weight restoration. This study was designed to determine whether a selective serotonin reuptake inhibitor would improve outcome and reduce relapse after weight restoration by contributing to maintenance of a healthy normal weight and a reduction of symptoms. Methods: We administered a double-blind placebo-controlled trial of fluoxetine to 35 patients with restricting-type anorexia nervosa. Anorexics were randomly assigned to fluoxetine (n = 16) or a placebo (n = 19) after inpatients weight gain and then were observed as outpatients for 1 year. Results: Ten of 16 (63%) subjects remained on fluoxetine for a year, whereas only three of 19 (16%) remained on the placebo for a year (p = .006). Those subjects remaining on fluoxetine for a year had reduced relapse as determined by a significant increase in weight and reduction in symptoms. Conclusions: This study offers preliminary evidence that fluoxetine may be useful improving outcome and preventing relapse of patients with anorexia nervosa after weight restoration. Biol Psychiatry 2001;49:644-652 (C) 2001 Society of Biological Psychiatry.
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