期刊
BIOCHEMISTRY
卷 50, 期 42, 页码 8983-8985出版社
AMER CHEMICAL SOC
DOI: 10.1021/bi201289c
关键词
-
资金
- National Institutes of Health (NIH) [P41EB002031]
It is challenging to find membrane mimics that stabilize the native structures, dynamics, and functions of membrane proteins. In a recent advance, nanodiscs have been shown to provide a bilayer environment compatible with solution NMR. We show that increasing the lipid to belt peptide ratio expands their diameter, slows their reorientation rate, and allows the protein-containing discs to be aligned in a magnetic field for oriented sample solid-state NMR. The spectroscopic properties of membrane proteins with one to seven transmembrane helices in q = 0.1 isotropic bicelles, similar to 10 nm diameter isotropic nanodiscs, similar to 30 nm diameter magnetically aligned macrodiscs, and q = 5 magnetically aligned bicelles are compared.
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