期刊
OPHTHALMOLOGY
卷 108, 期 4, 页码 784-787出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S0161-6420(00)00654-0
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Objective: To determine the vitreous concentration of brimonidine after topical administration of Alphagan. Design: Prospective observational case series. Participants: Eighteen patients scheduled for elective pars plana vitrectomy. Methods: Brimonidine tartrate, 0.2%, was topically administered twice or three times daily for 4 to 14 days preoperatively in 13 patients. Four patients served as controls, without application of brimonidine. A dry, undiluted vitrectomy specimen obtained intraoperatively was collected, frozen, and sent to an independent bioanalytical facility for quantitative determination of vitreous concentration of brimonidine using gas chromatography/mass spectrometry, Main Outcome Measures: The concentration of brimonidine in human vitreous. Results: All patients treated with brimonidine measured above the lower limit of quantitation with a mean vitreous concentration of 185 +/- 500 nM. All patients not treated with brimonidine measured at or below the lower limit of quantitation of 0.05 nM, There was a trend toward higher concentration in patients who were either aphakic or pseudophakic compared with those that were phakic, Conclusions: Topically applied brimonidine results in vitreous levels at or above 2 nM, the concentration shown to activate alpha (2)-receptors. (C) 2001 by the American Academy of Ophthalmology.
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