期刊
BIOCHEMISTRY
卷 50, 期 29, 页码 6289-6291出版社
AMER CHEMICAL SOC
DOI: 10.1021/bi2005448
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资金
- Lebensfeld Foundation
- National Science Foundation [0617956]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [0617956] Funding Source: National Science Foundation
In the budding yeast Saccharomyces cerevisiae, chromosome end protection is provided by a heterotrimeric complex composed of Cdc13 in association with the RPA-like proteins Stn1 and Ten1. We report here that the high affinity and specificity of the S. cerevisiae Cdc13 DNA binding domain for single-stranded telomeric DNA are not widely shared by other fungal Cdc13 proteins, suggesting that restriction of this complex to telomeres may be limited to the Saccharomyces clade. We propose that the evolutionarily conserved task of Stn1 and Ten1 (and their associated large subunit) is a genome-wide role in DNA replication rather than a telomere-dedicated activity.
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