期刊
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
卷 19, 期 2, 页码 175-182出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0736-5748(00)00090-3
关键词
motoneuron subtype identity; motor circuit formation
资金
- NINDS NIH HHS [NS 19640, NS 23678] Funding Source: Medline
Experiments in chick embryos using classical transplantation techniques introduced by Viktor Hamburger are reviewed; these demonstrated that chick-limb innervating motoneurons become specified by extrinsic signals prior to axon outgrowth and that they selectively grow to appropriate muscles by actively responding to guidance cues within the limb. More recent experiments reveal that fast/slow and flexor/extensor subclasses of motoneurons are distinct by E4-5 and that they exhibit patterned spontaneous activity while still growing to their targets. These observations are then related to the combinatorial code of LIM transcription factor expression, which has been hypothesized to specify motoneuron subtypes. (C) 2001 ISDN. Published by Elsevier Science Ltd. All rights reserved.
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