期刊
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
卷 124, 期 4, 页码 432-446出版社
KARGER
DOI: 10.1159/000053778
关键词
dendritic cells; allergy; animal models; immunology; asthma; antigen-presenting cells
Antigen-presenting dendritic cells are essential for the recognition and presentation of allergens to the cells of the immune system. Airway dendritic cells capture allergen in the mucosa and present it to naive T cells after migration into the draining lymph nodes. In this review article, we discuss the most recent findings from animal models of asthma, which highlight an essential role for these cells in the induction and maintenance of eosinophilic airway inflammation. This increasing knowledge might lead to the identification of new targets for the prevention and therapy of asthma, Copyright (C) 2001 S. Karger AG, Basel.
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