期刊
JOURNAL OF NEUROIMAGING
卷 11, 期 2, 页码 129-136出版社
SAGE PUBLICATIONS INC
DOI: 10.1111/j.1552-6569.2001.tb00022.x
关键词
multiple sclerosis; magnetic resonance imaging (MRI); brain; atrophy; disability
资金
- NINDS NIH HHS [1 K23 NS02210-01] Funding Source: Medline
Objective. Brain atrophy may occur early in the course of multiple sclerosis (MS) and may be associated with disability. Brain magnetic resonance imaging (MRI) of 114 MS patients (group A) were analyzed for regional atrophy (vs age-/gender-matched controls) and T-1 and T-2 lesions using 4-point rating systems. Thirty-five separate patients (group B) were analyzed for cortical atrophy (ordinal scale). third ventricular width. and total T-2 hyperintense lesion volume (computer assisted). In group A, regression modleing indicated that inferior frontal atrophy (P =.0003) and T-2,lesions in the pens (P =.02) predicted physical disability (Expanded Disability Status Scale [EDSS] score). Secondary progressive (SP) versus relapsing patients were predicted by inferior parietal (P =.002), superior parietal (P =.006), temporal (P =.008), inferior frontal (P =.01), superior frontal (P =.01), cerebellum (P =.01), occipital (P =.01), and midbrain (P =.02) atrophy. SP patients were also predicted by total atrophy (P =.01) and third ventricular enlargement (P =.03) but not T-1 or T-2 lesions. In group B, the regression model predicting EDSS score included only superior frontal atrophy (r =0.515, P =.002). Mean kappa coefficients of ordinal ratings were 0.9 (intraobserver) and 0.8 (interobserver). Ordinal ratings correlated well with quantitative assessments. The authors conclude that brain atrophy is closely associated with physical disability and clinical course in MS patients and can be appreciated using a semiquantitative MRI regional rating system.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据