期刊
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
卷 225, 期 1-2, 页码 218-225出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0304-8853(00)01261-0
关键词
alveolar macrophage; J774A.1 macrophage; phagocytosis; phagosome motion; cytoskeleton; lung fibrosis; magnetic iron-oxide microparticles; magnetopneumography; smoker; macrophage function; phagocytosis
Monodisperse ferrimagnetic iron-oxide particles of 1.4 mum geometric diameter were used to study alveolar macrophage functions (phagocytosis, phagosome transport) and cytoskeletal integrity in healthy subjects and in patients with idiopathic pulmonary fibrosis as well as in cultured macrophages. Dysfunctions in phagocytosis, in phagosome transport and cytoskeletal integrity correlated with an impaired alveolar clearance and could be induced in vitro by cytoskeletal drugs. (C) 2001 Elsevier Science B.V. All rights reserved.
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